April 14, 2010 - Trevena Inc., a leader in the discovery of G-protein coupled receptor (GPCR) biased ligands, announced the initiation of a Phase I clinical trial of TRV120027, a titratable i.v. agent designed for the treatment of acute decompensated heart failure. TRV120027 is a biased ligand that targets the angiotensin II type 1 receptor (AT1R) and induces a unique mode of signaling. It simultaneously blocks angiotensin-mediated G-protein signaling while stimulating AT1R-specific β-arrestin signaling. In preclinical studies, this biased signaling has demonstrated a unique range of biological effects that are highly advantageous to patients with acute heart failure... Trevena's Press Release -
Wednesday, June 2, 2010
Trevena : Clinical Development of TRV120027, a First-in-Class Biased Ligand
April 14, 2010 - Trevena Inc., a leader in the discovery of G-protein coupled receptor (GPCR) biased ligands, announced the initiation of a Phase I clinical trial of TRV120027, a titratable i.v. agent designed for the treatment of acute decompensated heart failure. TRV120027 is a biased ligand that targets the angiotensin II type 1 receptor (AT1R) and induces a unique mode of signaling. It simultaneously blocks angiotensin-mediated G-protein signaling while stimulating AT1R-specific β-arrestin signaling. In preclinical studies, this biased signaling has demonstrated a unique range of biological effects that are highly advantageous to patients with acute heart failure... Trevena's Press Release -
